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From: Immunosuppressive tumor microenvironment in the progression, metastasis, and therapy of hepatocellular carcinoma: from bench to bedside 6.2 Cancer Stem Cells cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), have been intensively studied in the past decade, focusing on the possible source, origin, cellular markers, mechanism study, and development of therapeutic strategy targeting their pathway .The first convincing evidence of CSCs was reported by Bonnet and Dick in 1997 by the identification of a subpopulation of leukemia cells expressing surface marker CD34, but not CD38
